There are more than 100 different types of arthritis, with different conditions and treatment methods. Two of the most familiar types are osteoarthritis (OA) and rheumatoid arthritis (RA). The symptoms of arthritis regularly develop over time, but they may also develop swiftly. Arthritis is most generally seen in adults over the age of 65, but it can also develop in children, teens and younger adults. Arthritis is more familiar in women than men and in people who are overweight.
Inflammatory Diseases In General
Inflamed tissue is a natural and essential response to the healing process. Without inflammation, injuries would not recover. Inflammation occurs in response to the invasion of an organism, exposure to a toxin or the presence of undermined or injured cells. The inflammatory response is a general intervention and not as specific as, for example, the generation of antibodies aimed to suppress a specific invader or threat. This prevailing response involves swelling (accumulation of fluids), heat, redness (increased micro-blood supply) and the impairment of function and pain at the affected site, which serves as a constant reminder to guard the situation until the healing process is concluded.
Inflammation is categorised as either acute or chronic. Critical inflammation is a brief reaction to an organism’s injury and ends when the affected tissue is healed. Chronic inflammation alternates. It can result from the existence of a maintaining cause, such as the presence of a foreign object; when an invading organism or toxin cannot be discharged or continuously appears; when an injury is not allowed to improve and instead is constantly agitated; or, lastly, from an over-reactive immune system that attacks itself, such as Crohn’s Disease.
Arthritis
Arthritis is inflammation of a joint attaching two bones such as the fingers, wrists, hips, back and knee joints. People enduring from arthritis often complain of pain in the afflicted joint, which is commonly followed by redness, a sensation of heat and minor swelling. Arthritis typically develops progressively over many years. Originally, it presents as an occasional mild achee in the joints which advances into chronic pains, stiffness, and swelling. The arthritis patient begins to avoid certain painful progress so as to guard against the pain, occurring in further stiffness, limited range of motion and reduced mobility. Arthritis has become the leading cause of inability in the U.S., with more than 46 million people enduring from various forms of physical difficulties.
Western medicine claims little specific knowledge if the causes or cures for this ailment. Nevertheless, more than one hundred different causes for arthritis are recognised, including gout and scleroderma and viral, bacterial or fungal infections. Limited treatments focus on suppressing pain and diminishing inflammation flare-ups.
One of the main classes of pharmaceutical drugs for arthritis, non-steroidal anti-inflammatory drugs (NSAIDs), can result in serious outgrowths and should be taken with an admonition. “Every year 41,000 older adults are hospitalized and 3,300 of them die from ulcers caused by NSAID’s. Thousands of younger adults are hospitalized”.
Cannabis Oil and Arthritis
In one invertebrate study, researchers from the UK, U.S. and Israel (2000) observed that cannabidiol (CBD) treatment in rats completely blocked the progression of both acute and chronic arthritis. In a variety of animal assays (a procedure for testing the effectiveness of a drug), cannabidiol-derived ajulemic acid exhibited efficacy in models for pain and inflammation. In a Worcester, Massachusetts study (2004) on rat adjuvant arthritis, ajulemic acid displayed a remarkable action in inhibiting the dissolution of inflamed joints.
Researchers from Calgary, Canada (2011), vaccinated the synthetic cannabinoid URB597 into osteoarthritic knees of rodents and realised that it significantly lessened pain. The mechanism was mediated via CB1 receptors. Specialists consider cannabinoids a possible novel strategy for treating osteoarthritis pain.
URB597 is an inhibitor of an enzyme (fatty acid amide hydrolase or FAAH) that tumbles down anandamide, whereby increasing anandamide presence and activity in the body. The endocannabinoid anandamide obliges relatively equally to CB1 and CB2. Ajulemic acid (HU239) is a synthetic cannabinoid hypothesized to be a CB1 agonist, while CBD has greater sympathy for CB2 than CB1.
The Arthritis Society of Canada is a strong advocate for the use of Rick Simpsons oil for arthritis and arthritis-related symptoms.
While more analysis has been done in the interim, the highlights are as follows:
• A 2011 study discovered that CBD helped to lessen inflammatory pain in rats by altering the way that pain receptors react to stimuli.
• A 2014 study of the existing body of investigation on animals resolved that CBD may be an effective treatment for OA.
• A 2016 research found that the topical application of CBD had the potential to ease pain and inflammation linked with arthritis.
• A 2017 comparison found that CBD might be a safe and helpful treatment for OA joint pain.
Though, to date, there a lack of scientific testimony to prove conclusively that CBD is an effective arthritis treatment for humans.
A 2006 research found that a cannabis-based mouth spray called Sativex helped to reduce arthritis pain. Nevertheless, the cannabis plant extracts that the company uses to make the spray accommodate both CBD and THC.
Cannabinoids, such as CBD, connect themselves to specialized receptors in a person’s brain and immune system.
One of these receptors, called a CB2 receptor, performs a role in the immune system by regulating pain and inflammation.
Researchers think that when CBD penetrates a person’s body, it may attach to CB2 receptors. Alternatively, it may generate the body to produce natural cannabinoids that attach to the CB2 receptors.
However, scientists think CBD affects the way that these receptors respond to the signals that they receive, possibly helping reduce inflammation and pain.
A 2008 examination of research into CBD and its possible mechanism of action suggested that CBD could play a role in chronic pain management.
In conclusion, CBD oil shows promise as a treatment for arthritis pain. If it hits receptors in the brain and immune system in the way that researchers believe, it may reduce inflammation and pain. If applied in synergy with THC, inflammation, pain relief, and joint protection are at its optimal efficacy.
Disclaimer: the principles contained here is not designed nor meant to be a substitute for professional medical advice, it is only achieved for educational confidences only. You should recognise full responsibility for the way you decide on to use this information.
Tags: Arthritis
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