Dr Mechoulam is the Israeli specialist who classified THC as the psychoactive compound in marijuana, and decades later he identified the brain's endocannabinoid system and the endogenous neurotransmitter anandamide. He is one of the most respected Israeli neuroscientists and has been a senior advisor to the Israeli government on marijuana policy and the ethics of analysis with human subjects. He mentioned his experiments demonstrating the neuroprotective effects of the endocannabinoid system in mice that have had traumatic injuries to the brain. He believes the neuroprotective effects of marijuana might eventually have applications for alternative medical specialty and psychiatrical conditions, as well as Alzheimer's and Parkinson's syndrome.
Another interesting discovery, one with implications for PTSD, is that the cannabinoid system is integrally related to memory, specifically to memory extinction. Memory extinction is that the traditional, healthy method of removing associations from stimuli. Dr Mechoulam explained that Associate in Nursing animal that has been administered an electrical shock once a precise noise can eventually ditch the shock once the noise seems alone for a few days. Mice while not cannabinoid systems merely always remember - they still cringe at the noise indefinitely.
This has implications for patients with posttraumatic stress disorder, World Health Organization answer stimuli that prompt them of their initial trauma even once it's not applicable. By aiding in memory extinction, marijuana may facilitate patients scale back their association between stimuli (perhaps loud noises or stress) and also the traumatic things in their past. Working with Army psychiatrists, Dr Mechoulam has obtained the required approvals for a study on posttraumatic stress disorder in Israeli veterans and hopes to start the study before long.
The Alternative Medical Journal: General use of cannabis for posttraumatic stress disorder Symptoms.
Despite the anecdotal evidence to the contrary, most of the experimental researches that have been conducted so far indicate that by and large the administration of exogenous cannabinoids such as vaporizing therapeutic cannabis might not be the foremost reliable nor effective suggests that of utilizing the ECB system to treat anxiety and dislike reminiscences like those shaped in posttraumatic stress disorder. For reliable and truly effective treatment of these conditions, it appears that restricting ECB breakdown by way of FAAH inhibition is the best target discovered so far within the ECB system. (The alternative ECB targets embody the 2 primary receptors CB1/CB2, vanilloid receptors, ECB reuptake, as well as ECB production.) To this end, Kadmus Pharmaceuticals, Inc. has began to specific serious interest in promoting a replacement FAAH matter they need developed, currently code-named KDS-4103. KDS-4103 seems to own plenty of potential from a medical specialty perspective. Even though it produces analgesic, anxiolytic, and anti-depressant effects it otherwise does not produce a classic cannabis-like effect profile and animals easily discriminate between THC and KDS-4103. All this indicates that KDS-4103 does not produce an “high†like THC and other direct CB1 agonists. KDS-4103 is orally active in mammals and fails to elicit systemic toxicity even at repeated dosages of 1,500mg/kg body mass. All alternative offered proof thus far conjointly suggests a awfully high therapeutic margin for KDS-4103. All in all, considering that the styles of events that typically precipitate posttraumatic stress disorder in most people usually conjointly involve pain, KDS-4103 looks like it should be around the perfect medication.
So what ought to all this mean to the individual? Anecdotal proof says by and enormous the employment of therapeutic cannabis provides a major improvement within the quality of life each for those full of this malady and for their family and friends. Whether or not this is often taking the fullest advantage doable of the ECB system within the treatment of posttraumatic stress disorder is nevertheless to be seen. Mostly the use of cannabis and THC to treat PTSD in humans appears to give symptomological relief at best. In and of itself, there's nothing wrong with symptomological relief. That's what taking pain pill for a headache, a water pill for top vital sign, opiates to control severe pain, or olanzapine for rapid-cycling mania is all about. We do have the potential, however, to do better than just treating symptoms of PTSD via activation of the cannabinoid receptors. With the correct combination of extinction/habituation medical care and also the even handed administration of a FAAH matter like KDS-4103, we have the potential to actually cure many cases of PTSD. For the nonce tho', symptomological treatments are all we have for more generalized anxiety and depression disorders.
If an individual were to want to get the most out of using therapeutic cannabis oil to improve a PTSD condition they should try to use low to moderate doses with as stable a blood level as doable for general anxiety and depression symptoms. Oral cannabis produces more stable blood levels. Since peak levels can turn out the foremost soporific result, administration of oral cannabis right before bed should produce the most benefits for improving sleep patterns. If the goal is to use cannabis oil to help the extinction of the response to PTSD triggers than small to moderate doses of cannabis vapours should be administered shortly before planned exposure to the trigger. A series of normal extinction sessions can turn out higher results than one session. If cannabis oil appears to make aversion, fear, or aversive memories worse then the dosage should be lowered. If feelings of fear do not improve with lower dose then discontinue use of cannabis oil as a fear-extinction aide.
In lightweight of all proof presently offered, it is striking that the FDA refuses to investigate cannabinoids for the treatment of anxiety disorders like PTSD yet they have recommended studies of MDMA, the controlled substance Ecstasy, for the treatment of PTSD (Doblin, 2002). Even if you do not accept cannabis oil as the answer itself, it should be hard to accept that by and large we still have not found effective and reliable ways that to utilize the ECB system in fashionable western medication.
Disclaimer: the principles contained here is not designed nor meant to be a substitute for professional medical advice, it is only achieved for educational confidences only. You should recognise full responsibility for the approach you opt on to use this information.
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